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KELCH-LIKE ECH-ASSOCIATED PROTEIN 1
Descriptors Found:
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DeCS
Descriptor
English
:
Kelch-Like ECH-Associated Protein 1
Descriptor
Spanish
:
Proteína 1 Asociada A ECH Tipo Kelch
Descriptor
Portuguese
:
Proteína 1 Associada a ECH Semelhante a Kelch
Synonyms
English
:
KEAP-1 Protein
KEAP1 Protein
KEAP 1 Protein
Kelch Like ECH Associated Protein 1
Tree Number:
D12.644.360.024.306
D12.776.157.057.067
D12.776.476.024.387
Definition
English
:
An adaptor protein characterized by an N-terminal
BTB-POZ DOMAIN
and six KELCH REPEATS that functions as a substrate for the E3
UBIQUITIN
LIGASE complex. It negatively-regulates
NF-E2-RELATED FACTOR 2
by targeting it for
ubiquitination
and degradation by the PROTEASOME. It also represses genes regulated by
ANTIOXIDANT RESPONSE ELEMENTS.
History Note
English
:
2017
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
56536
Unique Identifier:
D000072019
Occurrence in VHL
:
Similar:
DeCS
CID-10
LILACS